Posted by Debbie on November 28, 2003 at 14:43:48:
In Reply to: Re: One more thing. posted by Debbie on November 28, 2003 at 14:38:41:
Here's the one on Phenergan:
Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg of promethazine HCl. These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed.
: If you're contemplating or interested, here is the information from RXLIST.COM - the internet drug index on Zofran. It is prescribed quite frequently for severe nausea that is not helped by anything else. It is given to people on chemo. I actually had hyperemesis and it helped me tremendously:
: Teratogenic Effects: Pregnancy Category B. Reproduction studies have been performed in pregnant rats and rabbits at I.V. doses up to 4 mg/kg per day and have revealed no evidence of impaired fertility or harm to the fetus due to ondansetron. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
: Good Luck, let us know what you've decided to do. Did you try the Jolly Ranchers?
: : : Yeah, we're doing that. My mother-in-law takes care of Hannah while Mrs. Steve is at her part-time job during the day, and MIL has been coming over earlier and staying later. She's been a gigantic help. I think we're just getting frustrated at the whole thing and questioning whether this pregnancy was a good idea.
: : Steve,
: : I am so glad your MIL is becoming closer to Hannah. That is great that she is helping out!
: : I wish there was something I could do for Mrs. Steve. I tried talking to a good friend of mine who is a high-risk OB/GYN physician and he said what he usually recommends is vitamin B6, ginger, or an herb called Milk Thistle by Nature's Way which they sell at a health food store. He says that vitamin B6 is supposed to be the most effective of all. I did tell him nothing seems to be working for her and he said for her to have several small meals a day that she will tolerate and LOTS of rest. Has she had excessive vomiting? If things get worse, she may need IV fluids. I also mentioned Phenergan or Reglan to him and as I said, he too ded not feel it should be taken during the first trimester because it can cause birth defects as it is a class C drug and further studies are still needed to prove that the drug will not.
: : I hope she is feeling a bit better today. I hope you and your family had a Happy Thanksgiving.
: : Take Care. Keep me posted.